Listeria monocytogenes Spreads within the Brain by Actin-Based Intra-Axonal Migration
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چکیده
منابع مشابه
Listeria monocytogenes spreads within the brain by actin-based intra-axonal migration.
Listeria monocytogenes rhombencephalitis is a severe progressive disease despite a swift intrathecal immune response. Based on previous observations, we hypothesized that the disease progresses by intra-axonal spread within the central nervous system. To test this hypothesis, neuroanatomical mapping of lesions, immunofluorescence analysis, and electron microscopy were performed on brains of rum...
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Listeria monocytogenes is a Gram-positive bacilli that exhibits predilection to infect the central nervous system in immunocompromised individuals, especially those with hematologic malignancy, immunosuppressive agents use including corticosteroid, diabetes mellitus, and HIV infection. The most common manifestations include meningitis and rhombencephalitis, but brain abscess occurs rarely. Ther...
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The actin-based motility of the intracellular pathogen Listeria monocytogenes relies on ActA, a bacterial factor with a structural domain allowing it to mimic the actin nucleation-promoting activity of host cell proteins of the WASP/WAVE family. Here, we used an RNAi-based genetic approach in combination with computer-assisted image analysis to investigate the role of host factors in L. monocyt...
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The Listeria monocytogenes ActA protein induces actin-based motility by enhancing the actin nucleating activity of the host Arp2/3 complex. Using systematic truncation analysis, we identified a 136-residue NH(2)-terminal fragment that was fully active in stimulating nucleation in vitro. Further deletion analysis demonstrated that this fragment contains three regions, which are important for nuc...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 2015
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.00316-15